Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer’s Disease Neuropathological Changes
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چکیده
منابع مشابه
Identification of Genetic Modifiers of TDP-43 Neurotoxicity in Drosophila
Cytosolic aggregation of the nuclear RNA-binding protein TDP-43 is a histopathologic signature of degenerating neurons in amyotrophic lateral sclerosis (ALS), and mutations in the TARDBP gene encoding TDP-43 cause dominantly inherited forms of this condition. To understand the relationship between TDP-43 misregulation and neurotoxicity, we and others have used Drosophila as a model system, in w...
متن کاملRegulation of Autophagy by the Neuropathological Protein Tdp-43
NEUROPATHOLOGICAL PROTEIN TDP-43 Jayarama Krishnan Bose, Chi-Chen Huang and C.-K. James Shen Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China Running head: TDP-43 and Autophagy Address correspondence to: C.-K. James Shen, PhD, N523, Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Sec 2, Nangang, Taipei-115, Taiwan, ROC. Tel: +886-2-2789-9194...
متن کاملHippocampal Sclerosis, Argyrophilic Grain Disease, Tdp-43 and Dementia
Emerging technologies have been creating tools that enable pathologists to uncover brain changes practically invisible to old silver staining methods. These new tools coupled with the growing of well– structured brain banks focused in neurodegenerative diseases are resulting in the identification of new markers of dementia and better understanding on how each of these changes impact cognition. ...
متن کاملTDP-43 pathology occurs infrequently in multiple system atrophy.
AIMS AND METHODS The α-synucleinopathy multiple system atrophy (MSA) and diseases defined by pathological 43-kDa transactive response DNA-binding protein (TDP-43) or fused in sarcoma (FUS) aggregates such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration show overlapping clinico-pathological features. Consequently, we examined MSA for evidence of TDP-43 or FUS pathology uti...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2020
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-191040